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Page Photo of Sir William Osler. Medical archives of the Johns Hopkins Hospital. Page Caricature of Sir William Osler. Page My Osler residency team. Page 96— Examples of the Bills of Mortality.

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Page The illustration of new reproductive techniques is an adaptation of a similar illustration featured in the article. Courtesy of author. Page Chart of life expectancy. Figures based on data from the Organization for Economic Co-operation and Development. Adapted from the Wall Street Journal , March 17, Reprinted with permission. Public Domain.

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Page Physical activity and life expectancy. Data from S. Moore et al. Graphic courtesy of author and based on similar graphic in paper. Page Courtesy of Duke Medicine. Originally published in M. Dewhirst, et al. Miss Wanda Ruth Lunsford, twenty-six, must have been thinking about her own mortality the day she reported on a stunning experiment. Now imagine joining them surgically at their sides by peeling away a thin layer of skin and neatly stitching the exposed surfaces together. Miss Lunsford and her colleagues wanted to see what would happen.

The elder rats gained shinier, more colorful fur and clearer eyes, taking on the general appearance of the younger rats hitched to their sides. A four-hundred-day-old rat, more or less akin to a middle-aged man, lived nearly as long as the spry counterpart to which he was attached. When Miss Lunsford, a nutritionist and graduate student at Cornell University working in the lab of biochemist and gerontologist Clive McCay, shared these results at a gathering to focus on the problems of aging led by the New York Academy of Medicine, no one—not even Lunsford and her teammates—could explain this age-reversal transformation.


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The year was , the same year the Food and Drug Administration approved the polio vaccine, the power of the placebo effect was first written about, Albert Einstein died at the age of seventy-six, and Steve Jobs and Bill Gates were born. According to one description of the research, If two rats are not adjusted to each other, one will chew the head of the other until it is destroyed. But the pairs that survived gave a glimmer of hope for reversing the maladies we all face. It pretty much sputtered and stalled for the next sixty-odd years. Interestingly enough, you can get a sense of the climate in which these scientists were working by reading a line in the opening paragraph of their paper: Thus far man has made little progress in [studying aging] because human beings have chosen to expend their energies in improving the supposed comforts of living and methods of warfare.

The Lucky Years How to Thrive in the Brave New World of Health

The studies done in laboratory mice indicate that young blood can reverse some signs of aging when given to an older mouse, suggesting that young blood contains rejuvenation factors. This figure demonstrates the two ways to reverse aging in the studies. A Heterochronic parabiosis is the process by which an old and a young mouse are joined surgically at the skin where the arrow is pointing , thereby allowing their blood supplies to mix as the skin grows together.

B Plasma from a young mouse containing all of the proteins is regularly injected into the tail vein of an old mouse. When researchers at the University of California, Irvine, and the University of California, San Francisco, studied the life spans of old-young rat duos in , they noticed that the older rodents lived four to five months longer than controls did. However, early in the twenty-first century, a Stanford stem-cell biologist brought the technique back to life.

The Lucky Years: How To Thrive In The Brave New World Of Health

This ultimately paved the way for breakthroughs in cancer biology, endocrinology, and immunology today. So what is actually going on physiologically when the old and young combine? This procedure activates dormant stem cells in the older mouse, which turns back the clock and allows the stem cells to restore function to tissues. Stem cells are mother cells with the potential to become any type of cell in the body—from those that allow your heart to beat to brain cells that make you smart—and that also have the power to renew themselves or multiply.

The surprising conclusion drawn from this recent parabiotic research is that the secret to reversing aging organs is lying asleep inside each of us! Future research will figure out how exactly this age-reversal phenomenon works. In almost every tissue examined, including those of the heart, brain, and muscles, the blood of juvenile mice seems to zap new life into aging organs by awakening the sleeping stem cells through infusing substances normally associated with youth—proteins and growth factors that are particularly prominent in young blood but not old.

Youthful blood sparks the birth of new cells in the brain and the system that governs our sense of smell. Young blood can promote the repair of damaged spinal cords in older mice and improve learning and memory. A study from a laboratory in Canada in reported that fractured shin bones of old mice healed faster and better when they were joined to young mice rather than to mice their own age. What was once an implausible, preposterous idea swiftly cast aside has become a hypothesis in need of serious validation.

Are we de-aging animals? Are we resetting the aging clock? Or are we merely restoring function to tissues and helping them repair damage? Human trials are now underway using plasma transfusions. Plasma is a clear straw-colored liquid component of blood that contains a complex mixture of substances and proteins, some of which help the blood to clot. In , a clinical trial in California became the first to start testing the benefits of young plasma in older people with dementia.


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  • Clinical trials in other disease areas are scheduled to begin in I am planning clinical trials in patients with advanced cancer that have failed treatments. Almost 90 percent of pediatric cancer is curable. If I can convince the body it is young again, maybe I can cure cancer. We also need to figure out how much and how often to give the plasma. Verified purchase: Yes Condition: New. Skip to main content. Agus , Hardcover 2 product ratings 5. About this product. New other.

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    Make an offer:. Stock photo. Brand new: lowest price The lowest-priced brand-new, unused, unopened, undamaged item in its original packaging where packaging is applicable. Edition: 1. Format: Hardcover Condition: New! Other notes. See details.


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    • See all 11 brand new listings. Buy It Now. Add to cart. Agus , Hardcover. About this product Product Information Bestselling author David Agus unveils the brave new world of medicine, one in which we can take control of our health like never before and doctors can fine-tune strategies and weapons to prevent illness. In his first bestseller, "The End of Illness," David Agus revealed how to add vibrant years to your life by knowing the real facts of health. In this book, he builds on that theme by showing why this is the luckiest time yet to be alive, giving you the keys to the new kingdom of wellness.

      Medicine is undergoing rapid change.

      The Lucky Years

      In the old world, you followed general principles and doctors treated you based on broad, one-size-fits all solutions. In this new golden age, you'll be able to take full advantage of the latest scientific findings and leverage the power of technology to customize your care.

      Only those who know how to access and adapt to these breakthroughs--without being distracted by hyped ideas and bad medicine--will benefit. Imagine being able to get fit and lose weight without dieting, train your immune system to fight cancer, edit your DNA to avoid a certain fate, erase the risk of a heart attack, reverse aging, and know exactly which drugs to take to optimize health with zero side effects.

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